Mitochondria play a crucial role in cytoprotection, cellular senescence, tumor metabolism, and inflammation. One of the key mechanisms regulating these processes is the transport of potassium ions across the inner mitochondrial membrane, mediated by specific potassium channels. The latest review article, Mitochondrial potassium channels: New properties and functions, published in Biochimica et Biophysica Acta (BBA) – Bioenergetics, …

We are thrilled to announce that the National Science Centre (NCN) has awarded two OPUS 27 grants, which will be conducted in collaboration with the Department of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences-SGGW. Project 1: „Mitochondrial potassium channels as sensors and regulators of redox signaling”, PI dr hab. Bogusz Kulawiak …

The 15th Annual WMS Meeting on Targeting Mitochondria, held October 29-31, 2024 in Berlin, Germany. 112 presentations presented innovative research and advances in mitochondrial science to 151 attendees from 41 countries. Poland was represented by 4 attendees from 3 different laboratories. The Intracellular Ion Channels Lab from the Nencki Institute was represented by Dr. Monika …

Warsaw, Poland – October, 2024 – We are proud to announce the 25th anniversary of Intracellular Ion Channels Laboratory (1999-2024). Over the past quarter-century, the laboratory has been at the forefront of research, significantly advancing our understanding of intracellular ion channel function, particularly mitochondrial potassium channels, and their implications in cellular physiology and pharmacology. Milestones …

On September 25-27, 2024, another international conference, the 29th Kraków Conference on Endothelium, took place in Krakow. The conference focused on diseases related to the cardiovascular system. Lectures were presented in IX sessions and concerned: Vascular Aging; Vascular Inflammation, Platelets and Thrombosis; Tissue Factor Pathway Inhibitor (TFPI) and Vascular Wall; Inflammation Resolution; Cardio-vasco-oncology; Heterogeneity of …

The 22nd European Bioenergetics Conference (EBEC2024) held in Innsbruck, Austria, from August 26th to 31st, was a remarkable event that brought together 501 participants from 44 countries.  Poland was well-represented with 15 participants, including three members from our Laboratory. Joanna Lewandowska presented an insightful poster titled “Straight from the Heart – Infrared Light Regulation of …

We are excited to announce that the Laboratory of Intracellular Ion Channels at the Nencki Institute, led by Prof. Adam Szewczyk, has been awarded two prestigious grants from the National Science Center. The first project (OPUS 2023/51/B/NZ5/00999) with Prof. Adam Szewczyk as Principal Investigator running from June 2024 to June 2028 aims to investigate the …

In May 2024, Piotr Koprowski and Bogusz Kulawiak visited the Institute of Physiology of the Czech Academy of Sciences in Prague. The purpose of the visit was to present our research and discuss potential collaborations between our lab and the laboratories of the Institute of Physiology CAS. The meeting was very productive, and we established …

In a study entitled „Interaction of ROMK2 Channel with Lipid Kinases DGKE and AGK: Potential Channel Activation by Localized Anionic Lipid Synthesis” published in Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids, researchers Milena Krajewska, Mateusz Możajew,  Sławomir Filipek, and Piotr Koprowski have unveiled novel insights into the regulation of the ROMK2 …

Today, a review paper authored by Joanna Lewandowska, Barbara Kalenik, Antoni Wrzosek, and Adam Szewczyk (Intracellular Ion Channels Laboratory at Nencki Institute) sheds light on the profound influence of redox reactions on mitochondrial potassium channels, elucidating their pivotal role in cellular functions. Titled „Redox Regulation of Mitochondrial Potassium Channels Activity,” published in Antioxidants, this comprehensive …